IDT is the leading manufacturer of custom oligonucleotides and proprietary technologies for genomics applications. Our work is complex and cutting-edge, and our team members are curious, creative thinkers who understand that good data drives smart decisions. At IDT, we realize that although science may be uniform, people are unique. We promote a culture where engaged people are motivated and have opportunities to achieve their full potential, as part of one global team.
IDT is proud to work alongside a community of nine fellow Danaher Life Sciences companies. Together, we're pioneering the future of science and medicine, developing products that enable researchers in the fight to save lives.
Job Title: Staff Scientist
Location: Coralville, IA
The Enzyme Development team is seeking a talented Staff Scientist with expertise in protein biochemistry to develop enzymes used in: Genome Editing, Gene Expression, Genotyping, Next Generation Sequencing and Synthetic Biology. This position is a hands-on, laboratory-based position in Coralville, Iowa.
The candidate will work alongside other team members to characterize purified proteins by measuring kinetic parameters such as enzyme activities and binding affinities using UV-VIS absorbance, fluorescence, chemiluminescence, circular dichroism, binding assays, and coupled enzymatic assays in vitro. The position requires maintaining detailed records of work, creation of formal documents and presentations, participation in the technology transfer process to IDT's commercial production group.
The successful candidate will have the opportunity to support and develop early research projects as well as be part of a dynamic and innovative team where they will contribute their knowledge and technical skills to the growth of IDT's new product development pipeline. The candidate will be responsible for cloning, sequencing, optimizing upstream and downstream bioprocessing and final characterization of protein products. The successful candidate will have prior exposure and or experience with: protein expression, operation of AKTA FPLC chromatography systems, various resins (affinity, IEX, HIC, mix-mode, SEC), tangential flow filtration, analytical HPLC, LC-MS spectral analysis, assay development, and enzyme kinetics.
Execute bench experiments using variety of molecular biology, cell biology, biochemical, biophysical, and general laboratory techniques to innovate protein-based Genomics products offered by IDT. Primary duties will include bacterial fermentation and collection, protein purification, quantification, and detection of unwanted biological activity. Additional technology exposure will include growing cells in culture, nucleic acid isolation, qPCR, PCR, DNA quantification, DNA and RNA sequencing using next-generation sequencing.
Conduct experimentation in support of optimization of analytical methods to characterize protein products which include, but not limited to: pre-steady-state enzymatic activities, binding affinities, quantification of various host cell proteins and gDNA.
Drafts work outline, reviews with supervisor and executes experiments under minimal oversight. Analyze, summarize, and communicate experimental results to team members.
Collaborates with multidisciplinary teams to bring projects to a successful conclusion while ensuring timelines are met.
Engage in behaviors that mirror Danaher Core Behaviors of: apply insights, instill trust, deliver results and wins as a team.
Bachelor's degree (in Biochemistry, Biology, Chemistry, or a related life sciences field) with ten or more years relevant lab experience required
Master's degree (in Biochemistry, Biology, Chemistry, or a related life sciences field) with eight or more years relevant lab experience preferred
Ph.D. degree (in Biochemistry, Biology, Chemistry, or a related life sciences field) with five or more years relevant lab experience preferred
- Experience characterizing proteins
- Experience with upstream and downstream bioprocessing
- Experience in developing enzymatic assays
- Familiarity with scientific statistical methods
Other Job Qualifications:
Energetic, self-motivated, goal-orientated, and result-driven self-starter.
Experience with technology transfer from R&D to commercial manufacturing
Experience leading complex projects and acting as a technical expert within a multi-member cross-functional team
Exert up to 20-50 lbs. of force occasionally and/or up to 10-15 lbs. of force frequently.
What We Offer:
Generous Paid Time Off Accruals
16 Hours PAID Volunteer Time Off
10 Paid Holidays
Up to eight (8) weeks of 100% paid parental leave to eligible U.S. associates
401(k) with Company Match
Medical, Dental, and Vision Insurance Options
Integrated DNA Technologies (IDT) conducts drug screens and background checks on applicants who accept employment offers.
When you join us, you'll also be joining Danaher's global organization, where 80,000 people wake up every day determined to help our customers win. As an associate, you'll try new things, work hard, and advance your skills with guidance from dedicated leaders, all with the support of powerful Danaher Business System tools and the stability of a tested organization.
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